e-book Tutorials in Biostatistics: Statistical Modelling of Complex Medical Data (Volume 2)

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Practitioners in healthcare-related professions, ranging from clinical trials to care delivery to medical device design, as well as statistical researchers in the field, will benefit from this book. Permissions Request permission to reuse content from this site. Woodall, Benjamin M. Adams and James C. Undetected location. NO YES. Statistical Methods in Healthcare. Selected type: Hardcover.

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This is a dummy description. With a focus on finding solutions to these challenges, this book: Provides a comprehensive, in-depth treatment of statistical methods in healthcare, along with a reference source for practitioners and specialists in health care and drug development. Offers a broad coverage of standards and established methods through leading edge techniques.

Uses an integrated, case-study based approach, with focus on applications. Looks at the use of analytical and monitoring schemes to evaluate therapeutic performance. Features the application of modern quality management systems to clinical practice, and to pharmaceutical development and production processes. This content was uploaded by our users and we assume good faith they have the permission to share this book. If you own the copyright to this book and it is wrongfully on our website, we offer a simple DMCA procedure to remove your content from our site. Start by pressing the button below!

No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning or otherwise, except under the terms of the Copyright, Designs and Patents Act or under the terms of a licence issued by the Copyright Licensing Agency Ltd, 90 Tottenham Court Road, London W1T 4LP, UK, without the permission in writing of the Publisher. This publication is designed to provide accurate and authoritative information in regard to the subject matter covered.

It is sold on the understanding that the Publisher is not engaged in rendering professional services. If professional advice or other expert assistance is required, the services of a competent professional should be sought. Lisa M. Sullivan, Kimberly A. Moonseong Heo, Myles S.

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Download Tutorials In Biostatistics. / Volume 2, Statistical Modelling Of Complex Medical Data

Sullivan, Joseph M. Massaro and Ralph B. Nowhere is this more evident than in their application to biostatistics and, in particular, to clinical medical research. To keep abreast with the rapid pace of development, the journal Statistics in Medicine alone is published 24 times a year.


  • Christopher Jackson - MRC Biostatistics Unit;
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Here and in other journals, books and professional meetings, new theory and methods are constantly presented. However, the transitions of the new methods to actual use are not always as rapid. There are problems and obstacles. In response to these needs Statistics in Medicine initiated in the inclusion of tutorials in biostatistics. Later, both solicited and unsolicited articles were, and are still, developed and published. In all cases major researchers, methodologists and practitioners wrote and continue to write the tutorials.

Extended Reading

Authors are guided by four goals. The referenced literature is, however, not expected to constitute a major literature review.


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  8. The tutorials have become extremely popular and heavily referenced, attesting to their usefulness. To further enhance their availability and usefulness, we have gathered a number of these tutorials and present them in this two-volume set. Each volume has a brief preface introducing the reader to the aims and contents of the tutorials. Here we present an even briefer summary. We have arranged the tutorials by subject matter, starting in Volume 1 with 18 tutorials on statistical methods applicable to clinical studies, both observational studies and controlled clinical trials.

    Biostatistics

    Two tutorials discussing the computation of epidemiological rates such as prevalence, incidence and lifetime rates for cohort studies and capture—recapture settings begin the volume. Propensity score adjustment methods and agreement statistics such as the kappa statistic are dealt with in the next two tutorials. A series of tutorials on survival analysis methods applicable to observational study data are next.

    Finally, there are six tutorials on clinical trials. These range from designing vii viii PREFACE and analysing dose response studies and Bayesian data monitoring to analysis of longitudinal data and generating simple summary statistics from longitudinal data. All these are in the context of clinical trials. In all tutorials, the readers is given guidance on the proper use of methods. The subject-matter headings of Volume 1 are, we believe, appropriate to the methods.

    The tutorials are, however, often broader. For example, the tutorials on the kappa statistics and survival analysis are useful not only for observational studies, but also for controlled clinical studies. The reader will, we believe, quickly see the breadth of the methods. Volume 2 contains 16 tutorials devoted to the analysis of complex medical data. First, we present tutorials relevant to single data sets. Seven tutorials give extensive introductions to and discussions of generalized estimating equations, hierarchical modelling and mixed modelling. A tutorial on likelihood methods closes the discussion of single data sets.

    Genetic data methods are covered in the next three tutorials. Statisticians must become familiar with the issues and methods relevant to genetics.

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    The next two tutorials deal with the major task of data reduction for functional magnetic resonance imaging data and disease mapping data, covering the complex data methods required by multivariate data. Complex and thorough statistical analyses are of no use if researchers cannot present results in a meaningful and usable form to audiences beyond those who understand statistical methods and complexities. Before closing this preface to the two volumes we must state a disclaimer.

    Not all the tutorials that are in these two volumes appeared as tutorials.